While the students and teachers of Class Two are absorbed in looking at various zoo animals, a sneaky anaconda gobbles them up, until Molly sees what is happening and saves the day.
When a Shetland pony named Buttons keeps escaping from the local petting zoo, Nancy and the rest of the Clue Crew must try to figure out how he is getting out.
The Alden children investigate various mix-ups at a zoo run by their grandfather's friend in an effort to save it not only from pranksters but also from the town council.