River Tam and her brother Simon are hiding out from the totalitarian government that experimented with River's brain aboard a space-freighter. Captained by a down on his luck soldier, the crew of Serenity must take jobs, whether they are legal or not, while trying to avoid the Alliance, and keeping the Tams safe. Then things get out of control and the true extent of River's powers becomes known. At the same time, the Alliance sends a new Operative...

Human society has been decimated by a holocaust caused by biological warfare research gone wrong. The intent was to create super-soldiers, but a genetically-engineered virus turns infected humans into Hemophages. These human, vampire-like sub-species have enhanced physical abilities. In the infection-paranoid and technologically advanced society that follows, Violet is a singular Hemophage warrior battling the totalitarian dictator who is determined...