Last season, Sam and Dean Winchester faced their greatest challenge yet: the all-powerful Darkness and sister of God, who restored their mother to life. In Season Twelve, the Winchesters must not only contend with an escaped Lucifer and the British Men of Letters (who've come to end their hunting days), but they'll also have to relearn what it is to be a family again after all these years.

How do you deal with a fallout of Heavenly proportions? With the angelic Host's descent to Earth. Sam and Dean now face a world inhabited by thousands of powerful beings which soon form their own chaotic agendas. Before tackling the threat of the "loose nukes" roaming the globe, the Winchesters engage in their most personal conflict yet. Meanwhile, Castiel finds he's more vulnerable - and yet capable of more humanity - than ever. As the threat escalates,...