After losing virtually everything meaningful in his life, Benjamin trains to be a caregiver, but his first client, a fiercely independent teen with muscular dystrophy, gives him more than he bargained for and soon the two embark on a road trip to visit the boy's ailing father.

When their adopted eight-year-old son Max suddenly turns feral, Maya Shulman convinces her husband, Alex, to embark on a cross-country trip to Montana to track down Max's birth parents, which results in unexpected consequences and life-altering changes.

Years ago, Melanie followed her husband, Kurt, from New England where their two young sons were thriving to the suburbs of Atlanta. She's made a life as a metal sculptor, but when Kurt leaves her, having the tools to cut up their marriage bed is small consolation. When her best friend makes her buy a ticket to their high school reunion, and an old flame gets in touch to see if she's going, Melanie fantasizes that returning to her past might help her...

"Dara, savvy in business but not so savvy in love, has unexpectedly found success running a monthly tag sale after losing her job and inheriting her uncle's farmette in Maryland. Colleen, feeling underappreciated and in a rut with her husband and kids, rents a stall at Dara's tag sale, and now the two women are embarking on a two-week antiquing/thrift shopping roadtrip to Florida in the hopes of finding some diamonds in the rough to fix up and sell....

Fourteen-year-old Jess' beliefs falter when her evangelical father packs up the family, including her secretly pregnant older sister and her long-suffering mother, to travel across the country and save souls ahead of the anticipated end of the world.