For one special security guard, tracking people down is a paranormal sort of hobby. Able to use his rare abilities to find people, David Dunn is suddenly given a job that seems more daunting than all the others before it. He'll need to find Kevin Wendell Crumb, and time is of the essence. But part of the problem is that Crumb is an extremely disturbed man and with 24 personalities, he's a lot more complicated than the others Dunn has found.

When young doctor Edward Newgate arrives at Stonehearst Asylum in search of an apprenticeship, he is warmly welcomed by Superintendent Dr. Lamb and a mesmerizing woman by the name of Eliza Grave. Edward is intrigued by Lamb's modern methods of treating the insane until a series of unusual events leads him to make a horrifying discovery, exposing Lamb's utopia and pushing Edward to the limits of his conscience.