It's early 2000 on New York City's Upper East Side, and the alienation of Moshfegh's unnamed young protagonist from others is nearly complete when she initiates her yearlong siesta, during which time she experiences limited personal interactions. Her parents have died; her relationships with her bulimic best friend Reva, an ex-boyfriend, and her drug-pushing psychiatrist are unwholesome. As her pill-popping intensifies, so does her isolation and determination...

Mother of a kindergartener, married to her police detective soulmate, Emma has a rewarding career as a doctor at the local hospital. When her son, Josh, is diagnosed with a rare form of cancer, she is determined to save him. Emma makes the risky decision to sell opioids to fund the life-saving treatment Josh needs. When somebody ends up dead, a lethal game of cat and mouse ensues-- with her own husband leading the chase. With her son's life hanging...