Lyra and Pantalaimon (now a pine-marten) are back at Oxford. But their peace is shattered by Ragi, the daemon of the witch Yelena, who is searching for a healing elixir to cure his witch.
When Malcolm finds a secret message inquiring about a dangerous substance called Dust, he finds himself embroiled in a tale of intrigue featuring enforcement agents from the Magisterium, a woman with an evil monkey daemon, and a baby named Lyra.
Accompanied by her daemon, Lyra Belacqua sets out to prevent her best friend and other kidnapped children from becoming the subject of gruesome experiments in the Far North.