Adam is a handsome but intriguing young man who has Asperger's syndrome and has led a sheltered existence. Then he meets his new neighbor, Beth. She is a beautiful, cosmopolitan young woman who pulls him into the outside world, with funny, touching and entirely unexpected results. Their implausible and enigmatic relationship reveals just how far two people from different realities can stretch in search of an extraordinary connection.

Mary is a lonely eight-year-old in the suburbs of Melbourne. Struggling with questions that no one can answer, she writes to Max, an obese 44-year-old Jewish man with Asperger's Syndrome living in New York City, which starts a friendship that spans 20 years and two continents.