In the summer of 1727, Quill and his friends are put ashore on a remote sea stac to harvest birds for food, and only the end of the world can explain why no boat returns to collect them.
Having been raised believing he will die before he reaches the age of fourteen, Pepper Roux runs away on his fourteenth birthday in an attempt to elude his fate, assumes another identity, and continues to try to outrun death, no matter the consequences.
When a diphtheria outbreak forces twelve-year-old Cissy to leave her Oklahoma hometown in the 1890s, she and her two classmates embark on a wild adventure down the Missouri River with a team of traveling actors who are living on a dilapidated paddle steamer.